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Wheat. © INRA, BRUNEAU Roland

New perspectives to improve wheat: the reference sequence of wheat genome is finally a reality

The International Wheat Genome Sequencing Consortium (IWGSC), of which INRA is a leading member, published the first wheat genome reference sequence in Science, on 17 August 2018. French research teams from INRA, CEA, and the universities of Clermont-Auvergne, Evry, Paris-Sud and Paris-Saclay contributed to the project, a scientific milestone due to the enormous complexity and size of the genome — five times larger than the human genome and forty times larger than the rice genome. This achievement will make it possible to identify genes of agronomic interest, opening new perspectives to improve bread wheat varieties and crops in order to face the challenges of the future. This reference sequence also represents a significant step towards understanding how this complex genome functions and evolves.

Updated on 08/20/2018
Published on 08/17/2018

With over 220 million ha, bread wheat (Triticum aestivum L.) is the most widely grown cereal crop in the world and a staple food for 30% of the human population. Along with rice, wheat is the most widely consumed cereal, accounting for almost 20% of the average daily nutritional requirements of human beings. To meet the ever-changing demands of a growing world population, while still maintaining sustainable social and environmental conditions, wheat productivity needs to increase by 1.7%. An increment of this size will require unprecedented progress—the like of which has not been seen since the Green Revolution of the 60s—both in wheat improvement and agronomic practices.
On 17 August 2018, The International Wheat Genome Sequencing Consortium (IWGSC) published in Science the description and analysis of the wheat reference genome sequence, which they had announced in January 2016. This resource is the result of the work of over 200 researchers from 73 research institutes in 20 countries. It provides  valuable tools to face the agricultural challenges of the future, since it will allow a faster identification of genes responsible for traits of agronomic interest.  

Over 107,000 genes identified and 4 million molecular markers developed

The analysis of this sequence has led to the precise location of over 107,000 genes, some of which are potentially involved in grain quality, disease resistance, and tolerance to drought. Moreover, it has allowed researchers to develop over four million molecular markers, including some currently being used in gene selection programs.
Besides its contribution to wheat improvement, this sequence also allows researchers to better understand the bread wheat genome, one of the biggest and most complex in the plant kingdom. Now, they can study the regulation of genome organization and gene expression, and even reveal the evolution mechanisms that have shaped this genome since its formation, around 10,000 years ago.
Although it is the result of 13 years of work and constitutes a major contribution to the scientific community, the reference genome sequence is only the first step. IWGSC’s research teams are already working on new challenges, most notably, a functional study on the integral elements of this sequence and the characterization of the genetic diversity of wheat and other related species, in order to identify new genes and alleles of agronomic interest.


Scientific contact(s):

  • Etienne Paux (33 ) Joint Research Unit on the Genetics, Diversity and Ecophysiology of Cereals, INRA, Clermont Auvergne University
  • Frédéric Choulet (33 4 43 76 15 45) Joint Research Unit on the Genetics, Diversity and Ecophysiology of Cereals, INRA, Clermont Auvergne University
Press Relations:
INRA News Office (33 1 42 75 91 86)
Associated Division(s):
Plant Biology and Breeding
Associated Centre(s):


IWGSC (2018) Shifting the limits in wheat research and breeding using a fully annotated reference genome. Science. http://science.sciencemag.org/cgi/doi/10.1126/science.aar7191