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RESTAURANT  collectif du centre de Jouy, chaque matin 150 baguettes de pain sont coupés pour le service du midi.. © @INRA, NICOLAS Bertrand

A natural protein, Elafin against gluten intolerance?

Scientists from INRA and INSERM (France) in collaboration with scientists from McMaster University (Canada) and the Ecole polytechnique fédérale of Zurich (Switzerland) have shown that Elafin, a human protein, plays a key role against the inflammatory reaction typical of celiac disease (gluten intolerance). They have also developed a probiotic bacterium able to deliver Elafin in the gut of mice. This innovation, published online in the American Journal of Gastroenterology on 8 April 2014, paves the way to new strategies to treat gluten intolerance.

Updated on 04/14/2014
Published on 04/07/2014
Contact(s)
Scientific contact(s):

Press Relations:
INRA News Office (+33 1 42 75 91 69)
Associated Division(s):
Microbiology and the Food Chain
Associated Centre(s):
Jouy-en-Josas

Reference

Heather J. Galipeau, Michelle Wiepjes, Jean-Paul Motta, Jessica D. Schulz, Jennifer Jury, Jane M. Natividad, Ines Pinto-Sanchez, Daniel Sinclair, Perrine Rousset, Rebeca Martin-Rosique, Luis Bermudez-Humaran, Jean Christophe Leroux, Joseph Murray, Edgardo Smecuol, Julio C. Bai, Nathalie Vergnolle, Philippe Langella and Elena F. Verdu. Novel Role of the Serine Protease Inhibitor Elafin in Gluten-Related Disorders. American Journal of Gastroenterology, 8 April 2014. DOI : 10.1038/ajg.2014.48

Pending Patent US61/827074 "TREATMENT OF GLUTEN-ASSOCIATED DISORDERS"